The core technology employed by the OrganOx metra® has been in development for over 15 years. During this time both of the founders (Professor Peter Friend and Professor Constantin Coussios) have driven the development of organ preservation and maintenance, formerly at the University of Cambridge and latterly at the University of Oxford.
OrganOx Limited was founded in April 2008 as a spin-out from the University of Oxford.
Conventional cold preservation involves storage of the liver at 4˚C, using a non-physiological perfusion solution that aims to minimise liver decay. By contrast, warm preservation seeks to re-create an environment that mimics the human body by continuously perfusing at physiological pressures and flows with oxygen-carrying red cells at 37˚C and providing nutrition. The liver is therefore functional during the preservation period, producing bile, metabolizing glucose and maintaining a physiological pH. This enables objective assessment of organ performance prior to transplant, extended preservation times, and the potential use of organs that are presently being discarded.
OrganOx Limited was founded in April 2008 as a spin-out from the University of Oxford.
Conventional cold preservation involves storage of the liver at 4˚C, using a non-physiological perfusion solution that aims to minimise liver decay. By contrast, warm preservation seeks to re-create an environment that mimics the human body by continuously perfusing at physiological pressures and flows with oxygen-carrying red cells at 37˚C and providing nutrition. The liver is therefore functional during the preservation period, producing bile, metabolizing glucose and maintaining a physiological pH. This enables objective assessment of organ performance prior to transplant, extended preservation times, and the potential use of organs that are presently being discarded.
Phone: +44 1865 784156
Total raised: $180.72M
Founded date: 2008
Investors 5
| Date | Name | Website |
| - | Amadeus Ca... | amadeuscap... |
| - | Oxford Uni... | innovation... |
| - | Oxford Inv... | oxfordinve... |
| - | Perivoli I... | perivoliin... |
| - | BGF Ventur... | bgf.co.uk |
Funding Rounds 3
| Date | Series | Amount | Investors |
| 24.02.2025 | - | $142M | - |
| 17.07.2023 | IPO | $32.7M | - |
| 08.01.2020 | - | $6.03M | BGF Ventur... |
Mentions in press and media 18
| Date | Title | Description |
| 19.09.2025 | Startup Funding: Luke Rajah, BGF Early Stage Partner, Deep Tech and Life Sciences Luke Rajah is a Partner at BGF, focused on early-stage investments in deep tech and life sciences — two sectors where ... | From pioneering medtech breakthroughs to next-generation semiconductors, Rajah works closely with ambitious founders tackling some of the world's toughest challenges. In this Entrepreneur UK interview, he shares practical insights for early... |
| 10.09.2025 | British Business Bank CEO on BBB’s investor credentials, Sheffield HQ, and paying “civil service” salaries | Louis Taylor, the CEO of the British Business Bank (BBB), the UK’s biggest venture investor, has just come back from holiday, where he says he has “tried to shed” some excess weight amassed by the many corporate breakfasts and dinners he at... |
| 03.09.2025 | A 0.5 per cent pension shift could secure Britain’s tech supremacy | To solve the UK’s struggle to scale its world-class startups, we must unlock the nation’s vast pension funds for venture capital investment to fuel domestic growth and ensure technological sovereignty, says Dame Anne Glover This week, as le... |
| 30.08.2025 | European Tech Accelerates: HealthTech Leads, AI Drives Innovation, and Strategic Acquisitions Reshape Markets | European tech thrives. Ortivity secured €200M for German orthopaedic care expansion, a major HealthTech boost. Significant funding rounds propelled diverse sectors, like Framer's $100M raise. Key acquisitions reshaped the market, including ... |
| 29.08.2025 | Ortivity lands €200M to grow orthopaedic clinics, CrowdStrike acquires Spanish startup Onum, and Bitpanda snubs London | This week we tracked more than 55 tech funding deals worth over €658 million, and over 15 exits, M&A transactions, rumours, and related news stories across Europe. If email is more your thing, you can always subscribe to our newsletter ... |
| 25.08.2025 | OrganOx achieves one of the UK’s largest medtech exit to date | OrganOx, the Oxford-based medtech company behind pioneering liver perfusion technology that has transformed transplant outcomes worldwide, has been acquired in a deal valued at approximately $1.5 billion. The transaction also delivered BGF’... |
| 25.08.2025 | Oxford-based OrganOx achieves one of the UK’s largest medtech exits at $1.5 billion valuation | OrganOx, an Oxford-based medtech company that developed technology to preserve donor livers outside the human body, has been acquired in a deal valued at $1.5 billion. This marks one of the UK’s largest medtech exits and delivers £175 milli... |
| 14.05.2025 | OrganOx Raises New Funding | OrganOx, an Oxford, UK-based commercial stage organ technology company, raised an undisclosed amount in funding. Backers included Intuitive Ventures, Terumo Ventures, and Piper Heartland Healthcare LLC. The company intends to use the funds ... |
| 24.02.2025 | Liver transplant specialist OrganOx raises $142M for tissue support system | OrganOx, with its system for actively preserving viable donor tissue ahead of a transplant procedure, has raised $142 million to expand its commercial reach and R&D. The company’s metra platform has collected regulatory approvals in the... |
| 24.02.2025 | OrganOx Closes $142M Equity Financing | OrganOx, an Oxford, UK-based organ medical technology company, raised $142M in equity funding. The round was led by new investor HealthQuest Capital with participation from existing investors BGF and Lauxera Capital Partners, along with add... |
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