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The Column Group
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The Column Group

https://www.thecolumngroup.com
Last activity: 27.12.2025
Active
Invests in categories: DrugBioTechDevelopmentPlatformMedTechHealthTechHumanProductDesignScience
The Column Group (TCG) is a science-driven venture capital firm that makes significant financial and operational commitments to build early stage drug discovery companies based on their unique scientific platforms and potential to deliver multiple breakthrough therapeutics.

TCG’s investment strategy runs counter to the prevailing trend in life sciences venture capital toward assembling diversified portfolios of later stage, single product-orientated companies across multiple industry sectors, with proximity to value inflection points and the early identification of a Pharma “buyer” as key investment considerations.

In contrast, TCG takes the long view in making investments, recognizing that significant time is often required to generate significant value. Our approach is not “building-to-exit.” Key variables, including scientific opportunities, the competitive and regulatory landscape, and Pharma priorities, can change very rapidly. Instead, TCG’s mission is the generation of fundamentally strong companies, built from the ground up based on great science and the ability to generate multiple differentiated product opportunities.

Rather than diversification, TCG emphasizes focus. We are dedicated to early stage drug discovery as the best source of a new generation of novel, highly effective human therapies. We believe that the most critical resources, such as great ideas, world class founders, and top quality managerial and scientific talent, are very rare and that concentrating them within a small cohort of companies is the key path to success.

TCG is about the bold pursuit of big ideas using innovative science to generate breakthrough therapies that address significant diseases. Our firm is committed to all facets of company building and brings together a rich combination of scientific, financial and operational expertise to shape promising science into a value-rich portfolio poised to have a profound impact on human health.
News
18
Portfolio
30
Mentions
16
Location: United States, California, San Francisco
Employees: 11-50
Investment Type: Venture Capital
Investment Stage: Pre-Seed; Seed; Series A; Series D; Series E

Portfolio 30

DateNameWebsiteTotal RaisedLocation
27.12.2025Atavistikatavistikbio.com$220MUnited Sta...
13.10.2025Nilo Thera...nilotx.com$101M-
31.05.2023Carmot The...carmot.us$150M-
15.02.2022KALLYOPEkallyope.com$479M-
07.10.2020A2 Biother...a2biotherapeutics.com$151.5M-
28.07.2020NURA BIOnurabio.com$213M-
17.07.2020Hexagon Bi...hexagonbio.com$232.3MUnited Sta...
-Eikon Ther...eikontx.com$1.02BUnited Sta...
-NURIXnurix-inc.com$145.1M-
-NGM Biopha...ngmbio.com$101MUnited Sta...
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News 18

DateTitleDescription
27.09.2023Dr. Dan Nomura joins The Column Group as iPartnerThe Column Group announced the recruitment of Dr. Dan Nomura to the firm’s renowned group of iPartners. Dr. Nomura is a Professor of Chemical Biology and Molecular Therapeutics in the Department of Chemistry and the Department of Molecular ...
16.08.2023Dr. Sarah Hymowitz Promoted from Venture Partner to PartnerCopyright © 2022. The Column Group | Privacy Policy | Terms of Use Website developed by CP Communications
16.08.2023Dr. Millie Ray Promoted from Principal to PartnerCopyright © 2022. The Column Group | Privacy Policy | Terms of Use Website developed by CP Communications
17.08.2022The Column Group Raises $1.23 Billion in Two New FundsWe are very excited to announce that we have closed the two newest funds of the TCG fund family – The Column Group V (“TCG V”), a $615 million fund focused on early-stage investments, and The Column Group Opportunity III (“TCG Opportunity I...
03.05.2022Dr. Hui Tian joins The Column Group as Venture PartnerThe Column Group announces the hiring of Dr. Hui Tian. Previously, Dr. Tian was a founding member of NGM Biopharmaceuticals and most recently served as Senior Vice President of Research. In this role, he was responsible for discovery resear...
25.11.2021Mr. Jeff Goater joins The Column Group as Venture PartnerThe Column Group announces the hiring of Mr. Jeff Goater. Previously, Mr. Goater served as Chief Executive Officer of Surface Oncology. Prior to Surface, he served as Chief Financial Officer of Voyager Therapeutics where he was one of the m...
25.11.2021Dr. Sarah Gillmor Hymowitz joins The Column Group as Venture PartnerThe Column Group announces the hiring of Dr. Sarah Gillmor Hymowitz. Previously, Dr. Hymowitz spent 22 years at Genentech rising to Vice President of Protein Sciences. In this role, she oversaw the large molecule drug discovery portfolio an...
25.11.2021TCG Announces the Addition of TCG iPartnersTCG’s iPartners represents a new ideation advisory group comprised of leading academic investigators and biotech entrepreneurs. Working closely with TCG’s Swanson Fellows and our core investment team, this group is dedicated to crafting inn...
29.01.2021Dr. Eric Olson joins The Column Group as Science PartnerThe Column Group announced the recruitment of Dr. Eric Olson to the firm’s renowned group of Science Partners. Dr. Olson is the founding Chair of the Department of Molecular Biology at The University of Texas Southwestern Medical Center. He...
-Dr. Helen Hobbs joins The Column Group as Science PartnerThe Column Group announced the recruitment of Dr. Helen Hobbs to the firm’s renowned group of Science Partners. Dr. Hobbs is Professor of Internal Medicine and Molecular Genetics at the University of Texas Southwestern Medical Center. She i...
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Mentions in press and media 16

DateTitleDescription
28.12.2025Atavistik Bio Secures $120 Million: Advancing Precision Therapies for HHT and MPNsAtavistik Bio secured $120 million in Series B funding. This substantial capital will advance two crucial therapeutic programs. An oral AKT1-selective inhibitor targets Hereditary Hemorrhagic Telangiectasia (HHT). A JAK2 V617F mutant-select...
27.12.2025Atavistik Bio: $120 Million Series B Raised To Advance Selective Allosteric Small-Molecule Programs In HHT And MPNsAtavistik Bio announced it raised a $120 million Series B financing to push two selective allosteric small-molecule programs into clinical proof-of-concept studies: an oral, AKT1-selective allosteric inhibitor for hereditary hemorrhagic tel...
21.12.2025Atavistik Bio Raises $120M in Series B FinancingAtavistik Bio, a Cambridge, MA-based developer of selective allosteric small molecule therapeutics, raised $120m in Series B financing. The round was led by Nextech Invest and The Column Group with participation from Lux Capital and new inv...
15.10.2025Nilo Therapeutics Secures $101M for Neuro-Immunology RevolutionNilo Therapeutics launched with $101 million Series A funding. The neuro-immunology biotech seeks to restore immune balance. It modulates neural circuits, targeting autoimmune and inflammatory diseases. Key investors include The Column Grou...
08.10.2025Immunology biotech Nilo launches with $101M and mission to harness neural circuitsNilo Therapeutics has launched with $101 million in series A funds to drive its ambition to harness neural circuits to restore immune homeostasis. The New York-headquartered company was founded by a trio of respected academics in Columbia U...
24.07.2025TCG Labs Soleil raises $400M for single-asset biotechs, expands R&D footprint to ChinaTCG Labs Soleil has secured $400 million to boost the firm’s ability to advance its biotech portfolio companies while also expanding its R&D capabilities globally. The San Francisco-based company’s fundraise is the exact same size as it...
04.09.2024Circle Pharma Secures $90 Million to Propel Innovative Cancer TherapiesIn the bustling heart of South San Francisco, Circle Pharma has struck gold. The clinical-stage biopharmaceutical company recently closed a $90 million Series D financing round. This infusion of capital is not just a financial boost; it’s a...
03.09.2024Circle Pharma Closes $90M Series D FinancingCircle Pharma, a San Francisco, CA-based clinical-stage biopharmaceutical company dedicated to discovering and developing cell-permeable macrocycles as a new class of therapies, raised $90M in Series D funding. The round was led by The Colu...
03.04.2024From generative chemistry to computational astrophysics, startups employ new methods to fight cancerHere are a few startups in the cancer space that made headlines recently The recent revelation of Princess Kate Middleton’s battle with cancer has sent ripples across the globe, reminding us that this disease knows no boundaries of status o...
17.08.2022The Column Group Raises $1.23 Billion in Two New FundsWe are very excited to announce that we have closed the two newest funds of the TCG fund family – The Column Group V (“TCG V”), a $615 million fund focused on early-stage investments, and The Column Group Opportunity III (“TCG Opportunity I...
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